Recognizing that very less number of research has been conducted on workforce agility, the current research aimed to examine the effect of open-book management on agile employees' performance for Mansoura University medical centers' staff. The originality of this research lies within that through investigating previous studies, the researcher found that previous studies examined the relationship between open book management and employee performance. Additionally, studies investigated the role of OBM on organizational agility. Employees' agile performance was ignored, and will be examined in this study. A sample of 383 is used from a population that includes 15945 members. Additionally, a stratified random sample of four types of medical centres' staff members include doctors, nurses, technicians, and employees. SPSS statistical program as well as AMOS were used for statistical analysis. The results of the statistical analysis showed that there is a significant effect of some dimensions of open book management on agile employees' performance.