The current study examines the nature of the relationships between psychological burnout, compassion fatigue, and turnover intentions among nursing staff members in the governmental sector. A sample of 365 nurses was surveyed. Data were analyzed using IBM SPSS AMOS 26. The results indicated a positive relationship between psychological burnout and turnover intentions, suggesting higher levels of burnout are associated with increased intentions to leave the job. Similarly, a positive relationship was found between psychological burnout, compassion fatigue and between compassion fatigue and turnover intentions among the tested sample. Most notably, the analyses identified compassion fatigue as a significant mediator in the relationship between psychological burnout and turnover intentions. This suggests that efforts to mitigate compassion fatigue may be helpful in reducing turnover intentions driven by psychological burnout. The study concludes with a discussion of these findings, including their theoretical and practical implications, recommendations, study limitations, and directions for future research.