Background: Climate change is caused by human activities and results in a rise in temperature, precipitation, sea level, and extreme weather events. Climate change has already affected and will continue to affect population health, such as malnutrition, diarrhea, malaria, dengue fever, injuries, and deaths. Aim: This research aims to evaluate the effect of nursing instructional module on pregnant women' knowledge and practice regarding climate change.  Research Design: A quasi-experimental (one group pre & post) was used in the study. Setting: The study was conducted at El-Ghamarawy maternal child health center at Beni-Suef University Hospital. Sample: A purposive sample of 116 pregnant women. Tools for data collection: Three tools were used to collect data; Tool (I): Structured interviewing questionnaire: which is divided into two parts Part 1: Demographic Characteristics, Part 2: Obstetric history. Tool (II): Pregnant Women' Knowledge Assessment Questionnaire Regarding Climate Changes. Tool (III): Pregnant Women's practice Assessment check list Regarding Climate Changes. Results of the current study revealed a highly statistically significant improvement in pregnant women's knowledge and practices regarding climate change. Conclusion: The current study concluded that the nursing instructional module had a significant positive effect on pregnant women' knowledge and practice regarding climate changes, which supports the research hypothesis Recommendations: Regular educational programs are needed for pregnant women to maintain and refresh their knowledge and practice regarding climate change