Background: Prosocial leadership in a healthcare organization can effectively meet the needs of nurses by focusing on their career development and growth, which may encourage green behavior that improves the quality and safety of patient care, motivates, innovates, and increases satisfaction, in addition to promoting organizational sustainability within the workplace. Aim: Determine the relationship between Prosocial Leadership and Organizational Sustainability and Nurses' Green Behavior as a Moderating Role. Setting: The study was implemented at surgical, medical, endoscopy, and emergency units at Menofia International Liver Institute one of the governmental university hospitals, Menoufia Governorate. Subjects: A simple random sample of nurses (n=286) with at least one year of experience. Instruments: Three instruments were used; prosocial leadership scale, organizational sustainability scale, and nurses' green behavior questionnaire. Results: Staff nurses' responses to total levels of prosocial leadership and organizational sustainability were at a high level. However, the nurse's green behavior was at a moderate level. There was a statistically significant positive correlation between prosocial leadership and organizational sustainability [r =.963, p =.000], and with nurses' green behavior [r =.922, p =.000]".  Also, a significant positive correlation was found between organizational sustainability and nurses' green behavior [r =.922, p =.000]. Conclusion: There was a statistically significant positive correlation between prosocial leadership and organizational sustainability and with nurses' green behavior. Recommendations: Provide an educational intervention program for nurse leaders on the importance of pro-social leadership to help organizations reach sustainability objectives and how nurses' green behavior affects the quality of care they provide and to create a healthy work environment.