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343201

Invasive candidiasis in intensive care units in Tunisia: A prospective matched case-control study

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Medical mycology

Abstract

Background:  Invasive candidiasis (IC) is widely recognized as a major cause of morbidity and mortality especially among patients hospitalized in intensive care units (ICU). Hence, we conducted a prospective matched case-control study in three ICUs of the university hospital Sahloul in Sousse region (Tunisia), with the aim of describing the epidemiology, microbiology and risk factors of IC, in order to provide a risk predictive model for early diagnosis of these infections in ICU. Methods: A prospective matched case-control study was conducted jointly between the microbiology laboratory and three ICUs for a period of seven months (February-August 2020). A case report form was used to collect data prospectively for each included patient. Patient's characteristics and risk factors were analyzed using univariate and multivariate conditional logistic regression models. Results: Out of 112 included patients, 30 patients had IC. The incidence rate of IC in ICU was 11.7 episodes per 1000 patient-days (86.4 per 1000 ICU admissions). Prolonged ICU stay (≥14 days) had a 3-fold increase in the risk of IC (p=0.003). Multivariate analysis showed that diabetes (p=0.035), cardiovascular disease (p=0.028) and recent surgery (p=0.004) were independent risk factors for IC. Non-albicans Candida species were responsible for 60% of IC cases and 70% of candidemia cases. Resistance to fluconazole was mainly seen among C. glabrata and uncommon Candida species. Conclusion: This study provides a risk predictive model for early diagnosis of IC in ICU, which can improve the diagnosis of these infections and contribute to guide targeted preventive and therapeutic antifungal strategies.

DOI

10.21608/mid.2024.267990.1789

Keywords

Invasive candidiasis, ICU, risk factors, early diagnosis, species distribution

Authors

First Name

MAHER

Last Name

BEN BRAHIM

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia

Email

maherov9@gmail.com

City

-

Orcid

0009-0009-2717-2092

First Name

Meriam

Last Name

BenHamida-Rebai

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia , Research Laboratory of Epidemiology and Immunogenetics of Viral Infections (LR14SP02), Sahloul University Hospital, University of Sousse

Email

benhamida.meriam@gmail.com

City

SOUSSE

Orcid

0000-0002-0966-3383

First Name

nihel

Last Name

Haddad

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia , Department of preventive and community medicine. Faculty of Medicine of Sousse, University of Sousse

Email

nihel.elhaddad@gmail.com

City

Sousse

Orcid

0000-0001-6859-4640

First Name

Lamia

Last Name

Tilouche

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia

Email

tilouchelamia@gmail.com

City

Sousse

Orcid

0000-0001-6568-6662

First Name

Sameh

Last Name

boughattas

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia

Email

sameh.boughattas@gmail.com

City

Sousse

Orcid

0000-0002-3565-5360

First Name

Farah

Last Name

Azouzi

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia

Email

azouzi.farah@gmail.com

City

Sousse

Orcid

0009-0006-8893-4765

First Name

Abdelhalim

Last Name

Trabelsi

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia, Research Laboratory of Epidemiology and Immunogenetics of Viral Infections (LR14SP02), Sahloul University Hospital, University of Sousse

Email

abdelhalim.trabelsi@gmail.com

City

Sousse

Orcid

0000-0002-7833-3273

First Name

Soumaya

Last Name

Ketata

MiddleName

-

Affiliation

Laboratory of microbiology, University Hospital Sahloul, Sousse, Tunisia

Email

soumayaketata@gmail.com

City

Sousse

Orcid

0000-0003-0245-4009

Volume

5

Article Issue

3

Related Issue

49567

Issue Date

2024-08-01

Receive Date

2024-02-05

Publish Date

2024-08-01

Page Start

1,020

Page End

1,031

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 5_Issue 3_Pages 1020-1031.pdf

PDF . 627.8kB

Link

https://mid.journals.ekb.eg/article_343201.html

Detail API

https://mid.journals.ekb.eg/service?article_code=343201

Order

14

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Invasive candidiasis in intensive care units in Tunisia: A prospective matched case-control study

Details

Type

Article

Created At

25 Dec 2024