Objectives: This study aimed to assess the efficiency of trigger sensitivity adjustment in patients with ventilator-induced diaphragmatic dysfunction (VIDD). Patients and methods: This was a randomized clinical trial based on data collected by observation of 60 MV patients with planned extubation in the Critical Care Department in Qasr Al-Ainy. (1) Vital signs: heart rate, respiratory rate, blood pressure, and oxygen saturation (So2), (2) Arterial blood gases (ABG): PH, PCO2 mmHg, HCO3 mEQ/Liter, PO2 mmHg, (3) Ventilator parameters: minute ventilation and tidal volume were measured pre- and after the sessions. Result: The mean ± SD of all outcomes (PH, Pco2, Hco3, Sao2, minute ventilation [MV], tidal volume [TV], respiratory rate [RR], heart rate [HR], systolic blood pressure [SBP], diastolic blood pressure [DBP]) pre- and post-intervention in both groups were presented in table 2. There were significant increases in Sao2 (Cohen d effect size =1.5) and TV (d=1.06), and significant decreases in Pco2 (d=2.5), MV (d=0.65), RR (d=1.43), HR (d=2.29), SBP (d=1.43), and DBP (d=2.04) within the sample group (p-value <0.05), whereas there were significant increases in Sao2 (d=1.94) and significant decreases in Pco2 (d=1.85), Hco3 (d=0.85), HR (d=1.67), SBP (d=1.76), and DBP (d=2.69) within the controlled group (p-value <0.05). Conclusion: We concluded that trigger sensitivity adjustment could be used as a translational mechanism for weaning from MV in ventilator-induced diaphragm dysfunction critically ill patients.