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301250

NEUROPROTECTIVE EFFECTS OF PHYLLANTUS DEBILIS ON RAT'S HIPPOCAMPUS

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Last updated: 04 Jan 2025

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Abstract

Phyllanthus debilis has the potential as an antioxidant and anti-inflammatory, suitable for application in neurodegenerative disorders such as cognitive impairment. This study aimed to examine the effect of P. debilis dichloromethane extract as a neuroprotector in rats treated with electroconvulsive shock (ECS). The rats were given the test substances for  20 days p.o, and ECS induction was held from day 15 to day 19. The Morris water maze (MWM) test determined the cognitive function, while hippocampus homogenates were used for biochemical studies. P. debilis showed the ability to reduce cognitive impairment in ECS-induced rats. The biochemical tests on the rat hippocampus showed a significant increase in catalase (CAT) activity and lipid peroxidase inhibition. The results aligned with anti-inflammatory activity, where TNF-α concentration showed significantly lower results than the ECS control. Overall results demonstrated the ability of P. debilis as a neuroprotective agent through the reduction of oxidative stress and inflammation.

DOI

10.21608/bfsa.2023.301250

Keywords

Electroconvulsive shock, cognitive impairment, Oxidative Stress, Inflammation

Authors

First Name

Lusi

Last Name

Dwita

MiddleName

Putri

Affiliation

School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung, 40132, Jawa Barat, Indonesia / Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia

Email

lusi_putridwita@uhamka.ac.id

City

-

Orcid

0000-0003-2678-0474

First Name

Maria

Last Name

Iwo

MiddleName

Immaculata

Affiliation

School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung, 40132, Jawa Barat, Indonesia

Email

maria@fa.itb.ac.id

City

-

Orcid

0000-0003-2856-939X

First Name

Elfahmi

Last Name

Elfahmi

MiddleName

-

Affiliation

School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung, 40132, Jawa Barat, Indonesia

Email

elfahmi@fa.itb.ac

City

-

Orcid

0000-0003-3586-5082

First Name

Rachmat

Last Name

Mauludin

MiddleName

-

Affiliation

School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha, 10, Bandung, 40132, Jawa Barat, Indonesia

Email

rachmat@fa.itb.ac.id

City

-

Orcid

0000-0002-3729-0254

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-22

Publish Date

2023-06-01

Page Start

529

Page End

535

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 529-535.pdf

PDF . 1.0MB

Link

https://bpsa.journals.ekb.eg/article_301250.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301250

Order

301,250

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

NEUROPROTECTIVE EFFECTS OF PHYLLANTUS DEBILIS ON RAT'S HIPPOCAMPUS

Details

Type

Article

Created At

25 Dec 2024