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Classification of Brain Neuroimaging for Alzheimer's Disease Employing Principal Component Analysis

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Last updated: 25 Dec 2024

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Abstract

Alzheimer's disease (AD) is one illness that significantly impacts people's lives. As AD worsens over time, it causes the death of brain cells. To assist a neurologist, a proposed classification method for AD progression is introduced in this paper. Pre-processing is applied to clean up artifacts from brain images. As biomarkers for AD diagnosis, three specific areas of the brain are utilized. Multiplicative intrinsic component optimization with an exemplar pyramid is employed for the three main biomarkers segmentation at a multi-scale. For feature extraction, the gray-level co-occurrence matrix is utilized. Finally, principal component analysis is incorporated for feature reduction, and based on the Euclidean distance the decision of the binary classifier is performed. The Alzheimer's Disease Neuroimaging Initiative baseline dataset is used with 311 subjects, 262 for training and 49 for testing. The proposed method achieved an accuracy of 96.296% for the classification between late mild cognitive impairment (LMCI) and cognitive normal (CN), 85.71% between early mild cognitive impairment (EMCI) and CN, 92% between AD and CN, 95.833% between EMCI and LMCI, 91.3% between AD and EMCI, and 84.21% between AD and LMCI. Evaluation results show that the proposed method enhanced the existing method's accuracy with less feature dimensionality.

DOI

10.21608/mjeer.2023.232914.1079

Keywords

Alzheimer's disease, bias field, brain segmentation, GLCM, MRI

Authors

First Name

Fatma elzahraa

Last Name

shehata

MiddleName

sayed

Affiliation

ASSUIT

Email

fatmaelzahraasayed95@yahoo.com

City

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Orcid

-

First Name

Mostafa

Last Name

Makkey

MiddleName

-

Affiliation

Electrical Engineering Department , Faculty of Engineering, Assuit University, Egypt.

Email

mymakkey@aun.edu.eg

City

-

Orcid

-

First Name

Shimaa

Last Name

A. Abdelrahman

MiddleName

-

Affiliation

Electrical Engineering Department , Faculty of Engineering, Assuit University, Egypt.

Email

shimaa.adly@aun.edu.eg

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-

Orcid

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Volume

33

Article Issue

1

Related Issue

45599

Issue Date

2024-01-01

Receive Date

2023-08-30

Publish Date

2024-01-01

Page Start

31

Page End

38

Print ISSN

1687-1189

Online ISSN

2682-3535

Link

https://mjeer.journals.ekb.eg/article_336986.html

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https://mjeer.journals.ekb.eg/service?article_code=336986

Order

336,986

Type

Original Article

Type Code

1,088

Publication Type

Journal

Publication Title

Menoufia Journal of Electronic Engineering Research

Publication Link

https://mjeer.journals.ekb.eg/

MainTitle

Classification of Brain Neuroimaging for Alzheimer's Disease Employing Principal Component Analysis

Details

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Article

Created At

25 Dec 2024