Introduction: Cardiovascular disease (CVD) is the primary cause of morbidity and death worldwide. The WHO estimates that CVD accounts for 32% of all deaths worldwide annually. Egypt has one of the highest rates of mortality from CVD regionally. In Egypt, CVD accounted for 46.2% of all fatalities. Research indicates a correlation between Helicobacter pylori (H. pylori) and a higher risk of CVD. This study aims to assess the link between H. pylori and CVD. Methods: This is a case-control study that was done on two groups complaining of dyspepsia from December 2022 till June 2023. The participants were 46 with high cardiovascular risk (cases) and the same number with low cardiovascular risk (controls). The Atherosclerotic CVD (ASCVD) risk was assessed by the Pooled Cohort Risk Estimator Plus. All participants were subjected to a structured interview using a pre-designed questionnaire. The association between H. pylori infection and cardiovascular risk was evaluated by a pooled cohort equation using logistic regression. Multivariate logistic regression tests were used by adjusting for confounders like gender, age, body mass index (BMI), smoking, lipids, diabetes (DM), and hypertension. Results: There was an increase in H. pylori infection (p = 0.04) in case group patients (74%) compared to control group patients (63%) which is significant with a statistically significant association with increased CVD risk (OR 1.661, 95%CI 0.682–4.043; P < 0.0001) and remained so after multivariable adjustment of confounders. Conclusions: H. pylori infection is a possible independent risk factor for CVD