Background : Families with Congenital Heart Diseases children experience a great level of anxiety and low self-efficacy. Information- Motivation- Behavioral Skills model provide mothers with guidance, empowerment and ideal use of health services that promote wellbeing and high quality of life. The study aimed to evaluate the application of Information- Motivation-Behavioral Skills model on mothers' care and quality of life of their children with Congenital Heart Diseases. Design: A quasi- experimental research design was utilized. Subjects: A purposive sample of 60 mothers with their children suffering from Congenital Heart Diseases who hospitalized or attended for follow up at Inpatient Pediatric Cardiac Unit and Outpatient Cardiac Clinic of Tanta Main University Hospital. Tools: Four tools were used; mothers' knowledge assessment questionnaire, mothers, motivational questionnaire, mothers' reported care sheet and children's quality of life scale. Results: There were a statistically significant difference in mothers, knowledge, social support and mothers, reported care scores as well as the quality of life of children from pre-test to posttests of the model application with positive correlation in between immediately after the model and one month later (p< 0.05).The study concluded that the Information- Motivation-Behavioral Skills model improves mothers' care and quality of life of their children with Congenital Heart Disease. The study recommended that the implementation of the Information- Motivation-Behavioral Skills model should be carried out for parents having Congenital Heart disease child to improve their lives