Background: Retinopathy of Prematurity is a multi-factorial preventive cause of childhood 
blindness. Using POINTS of care as preventive strategies may be significantly prevent 
occurrence of retinopathy of premature neonates.  The aim of the study was to evaluate 
nurses' performance regarding points of care for prevention of retinopathy of premature 
neonates. Subjects and Method: The study design used was descriptive. Setting: It was 
conducted at Neonatal Intensive Care Units of Tanta Main University Hospital & 
International Teaching Hospital. Subjects: All nurses (120) who are working in the 
aforementioned places. Tools: two tools were used: Tool I: Retinopathy Structured Interview 
Questionnaire, Tool II: POINTS of Care Observational Checklists. Results: nearly three 
quarters of the nurses had low level of overall knowledge about retinopathy of prematurity 
and POINTS of care. More than half of the nurses had unsatisfactory practice regarding 
POINTS of care. Conclusion: Nurses had low level of knowledge & unsatisfactory practice 
about retinopathy of prematurity and POINTS of care. Recommendations: Designing a 
training course for neonatal nurses concerning retinopathy of prematurity. Applying POINTS 
of care standardized protocol for prevention of retinopathy of premature neonates at neonatal 
intensive care units