Background Intussusception is a serious condition that occurs when one segment of the 
intestine invaginates leading to bowel obstruction. Nursing management involves 
comprehensive care, including pain management, fluid and electrolyte balance. Developing 
an educational program for nurses my help to improve children's outcomes and enhance 
nurses' performance. Aim: The current study was aimed to evaluate the effect of educational 
program regarding care of children with intussusception on nurses' knowledge and practice. 
Subjects and Method: A quasi experimental research design was used. Subjects: 
convenience sampling (60) nurses distributed as 30 nurses from Pediatric Surgical 
Department of Tanta University Hospital and 30 nurses from Pediatric Surgical Department 
of Elshatbi University Hospital. Tools: Two tools were used to collect data: Nurses' 
knowledge about intussusception structured questionnaire sheets and nurses' practices 
regarding intussusception observational checklist. Results: Most of the studied nurses had 
low level of knowledge about intussusception pre the educational program which was 
enhanced to high level level of knowledge after one month. A high percentage of nurses had 
unsatisfactory practice regarding care of children with intussusception before educational 
program, compared to the majority of them who had satisfactory practice immediately and 
one month after implementing the educational program. Conclusion: Implementing 
educational program for nurses had a significant effect on nurses knowledge and practice 
immediately and one month after education. There was statistically significant positive 
correlation between nurses' total knowledge and total practice. Recommendations: in
service training programs should be conducted periodically for all nurses caring for children 
with intussusception.