Background: Diaper Dermatitis (DD) is a prevalent skin condition among infants. In recent
times, various complementary skin-care approaches have been recommended, including
alternatives like sunflower oil and human breast milk. Despite these natural options, certain
chemical formulations persist in use, posing potential harm or providing little benefit. Aim:
To evaluate the effect of topical application of mothers' breast milk versus barrier cream on
healing of diaper dermatitis in infants. Design: A Randomized Controlled Trial design was
used. Subjects: A purposive sample of 62 infants and their mothers were included. Setting:
The study was conducted at the Pediatric Clinic affiliated to El-Fardoos Primary Health Care
Center at Mansoura city, Egypt. Tools of data collection: Two tools were used for data
collection: A structured questionnaire sheet for infants and their mothers and severity scale for
DD were used for data collection. Results: Mild to moderate pre-lesion scores were
comparable between both groups with no statistically significant difference. The post-lesion
scores on the 7th day for the breast milk group were significantly different from the barrier
cream group (p=0.005). Conclusion: Breast milk delivers more effective results than barrier
cream, in the treatment of infants with mild to moderate DD. Recommendations: The study
recommends developing a standardized protocol for the application of breast milk, for the
prevention and treatment of DD.