Background: The most prevalent condition affecting the neuromuscular junction (NMJ) and fatigability of skeletal muscles is myasthenia gravis. Aim of the Study: To assess the Effect of Teaching program on nurse's performance and patient outcomes for Myasthenie gravis. Research design: Quasi experimental research design was utilized in this study. Setting: The study was carried out at the neurological inpatient ward, intermediate unit, intensive care unit at Assiut University Hospital. Sample: This study was a purposive sample of thirty nurses who provided pre-and post-implementation care to patients with Myasthenia Gravis. A convenient sample of 40 patients with a diagnosis of Myasthenie gravis was divided into tow patient groups (20 in each): control and study. Tools: Tool I pre/post nurses knowledge assessment questionnaire, tool II pre/post nurses practice observational check list, tool III fatigue severity scale (FSS), tool IV MG Activities of Daily Living scale. Results: The majority of nurses showed a significant improvement in their mean scores after the teaching program (p= 0.001). However, before the program, their knowledge regarding fatigue in Myasthenie gravis (MG) patient was insufficient, and their understanding of managing fatigue was similarly inadequate. This was linked to their ability to assist patients with Myasthenia Gravies in performing activities of daily living (ADL).Conclusion: The Teaching program significantly improves nurses' knowledge and skills of nurses about patients with myasthenia gravis. Recommendation: An in-service training program for nurses caring for patients with Myasthenie gravis (MG) is essential to ensure they maintain up- to -date knowledge and skills in managing chronic neuromuscular disorder.