Background: Nurses need to be supported regarding the extensive spread of Artificial Intelligence technology in health care, where certain tasks may be automated and carried out autonomously with little human control, which can be a threat to job control; therefore, innovative behavior became a must for keeping up with rapid advancements in technology and communications aspects over the past few decades. Aim: Determine the relation between artificial intelligence and nurses‟ innovative behavior and determine the moderating role of Job control. Design: A descriptive, correlational research design was used. Setting: The current study was conducted in El-Araby Hospital in the Delta region of Egypt. Study subjects: A convenience sampling technique was used (n=242) on those working in critical care units and operating rooms. Instruments: Three instruments were used namely, artificial intelligence Practice Scale, Innovative Behavior Questionnaire (IBQ), and Job control Scale. Results: More than half of the studied subjects had a high level of job control and innovative behavior, while more than two-thirds of them had a moderate level of artificial intelligence. Conclusion: The existence of a moderate effect of job control on the relationship between the independent variable (artificial intelligence) and the dependent variable (nurses‟ innovative behavior) was supported. Recommendation: Healthcare leaders should support the career development needs of nurses and the requirement of special certification in the field of healthcare informatics to promote the rapid adoption of healthcare AI innovations and enhance nurses‟ job control.