Background: Worldwide, preeclampsia is an increasingly leading cause of maternal and fetal morbidity and mortality. Preeclampsia prevention requires an effective, ongoing, and easily accessible educational model. Aim: To evaluate the effect of virtual PRECDE model application on pregnant women's Knowledge and reported practices regarding preventive behaviors of preeclampsia. Design: A quasi-experimental research design (pre and posttest) was used. Settings: The study was conducted at Antenatal Outpatient Clinics in the New Obstetrics and Gynecology Hospital, Mansoura City, Dakahlia Governorate, Egypt. Subjects: A purposive sample of 118 high-risk pregnant women for preeclampsia. Tools: Three questionnaires were utilized; A structured interviewing questionnaire, knowledge questionnaire for Predisposing, Enabling, and Reinforcing factors (PRECEDE Model) and pregnant women's reported practices of preeclampsia preventative behaviors questionnaire. Results: There was statistically significant increase in the total knowledge scores of predisposing, enabling, and reinforcing factors both immediately and one month later. Furthermore, one month after the intervention pregnant women exhibited satisfactory practices towards preeclampsia preventive measures compared to pre-intervention. Also, the majority of high-risk pregnant women did not develop preeclampsia following the use of PRECDE Model intervention. Conclusion: The current study hypotheses were accepted where the application of virtual PRECEDE model was an effective tool to improve pregnant women's knowledge and practices regarding preventive behaviors of preeclampsia. Recommendation: Incorporating nursing interventions guided by the PRECEDE model into routine prenatal care for the expected high risk pregnant women to prevent the occurrence of preeclampsia.