Psychiatric patients are at higher risk of dying from COVID-19, making the concern of vaccination willingness crucial. Aim: This research aimed to assess the relationship between psychiatric patients' awareness of COVID-19 and their attitude toward its vaccine. Design: A descriptive-correlational design was used. Setting: The research was done at an outpatient clinic and inpatient psychiatric department of the neuropsychiatric and neurosurgery hospital at Assiut University Hospital. Sample: Included 186 psychiatric inpatients and 278 psychiatric outpatients. Tools: three tools were used; Tool (1): Structured interviewing questionnaire, Tool (2): Coronavirus (COVID-19) Awareness Scale, and Tool (3): Attitudes toward COVID-19 vaccines. Results: The research subjects have the highest mean score and SD of coronavirus concern (12.2±3.3), followed by exaggerated perception (5.2±2.1) and the lowest mean score is related to immunity perception (2.7±1.2). The mean rank of coronavirus concern is higher among outpatients than inpatients and there is a significant relation between outpatient and coronavirus concern (pvalue= 0.000). Conclusion: Psychiatric patients who have coronavirus concerns and have information about the virus have the wiliness to be vaccinated more those patients who have not aware of the pandemic of coronavirus. Also, it can be concluded that outpatients are more aware of COVID-19 as they are in more contact with mass media than inpatients. Recommendations: Implementation of educational programs about the effects and importance of vaccines against COVID-19