Recently Nano-technology is considered to be used in many applications and it has received an increasing attention in building materials. More experimental studies are required for understanding the real behaviour of modified concrete with Nanographene. In this paper, fifty-two tested specimens with different Nano-graphene types and different ratios were tested to study the behaviour of modified concrete specimens containing Nano-particles at various water-cement ratios. The specimens' dimensions were 100 mm 100 mm 400 mm. twelve tested specimens are control. In the first group, twenty tested specimens were prepared by adding Graf Pro nano graphene particles with ratios equal to 0.5% and 1% of cement weight. In the second group, ten specimens were prepared by adding (Graf Pro + Graf Max (9:1)) nano graphene particles with ratio equal to 0.50% of cement weight. In the third group, ten tested specimens were prepared by adding Graf Max nano graphene particles with ratio equal to 0.50% of cement weight. All these specimens at w/c=0.35 and 0.4. Comparison between the tested control specimens and results of tested specimens containing Nano-particles was done. The flexural and compression testing were recorded. The results showed that the use of Nano-particles enhances the microstructure of concrete by filling the harmful pores and dandifying the microstructure of cement paste. Finally, the Nano-particles resulted in significant increase in the flexural and compressive strength of concrete.