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345576

Role of Multi-Detector Computed Tomography in Tumor Response Evaluation of Conventional Trans-Arterial Chemoembolization in Hepatocellular Carcinoma

Article

Last updated: 24 Dec 2024

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Clinical Research (Medical)

Abstract

Background: The major liver cancer that affects people the most frequently is hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE), which combines the effects of targeted chemotherapy with ischemia necrosis brought on by arterial embolization, reduces tumor growth and increases survival. Conventional methods for evaluating therapy response, such as Response Evaluation Criteria in Solid Tumours (RECIST), which is based on tumor size reduction, perform inadequately in predicting the course of TACE treatment for HCC patients. Aim: To compare the currently available non-3D three-dimensional methods (modified RECIST) with the quantitative method of the index tumor as a modern and more accurate tool for evaluating the response of one of the most common tumors, HCC, after the treatment by TACE. Methods: We conducted a prospective comparative study on 55 patients with a diagnosis of HCC who underwent cTACE at the interventional radiology unit. Each participant was subjected to History Taking, laboratory investigations, and pathology assessment. Results: Most patients 42 (76.4%) were responders, while 13 (23.6%) were non-responders regarding the treatment response according to vRECIST. By both mRECIST and vRECIST methods in the assessment of the therapeutic response, it was found that both methods agree in the assessment of 11 patients had a partial response, nine patients had stable disease, four patients had a complete response, and two patients had progressive disease. Conclusion: With a significant difference between vRECIST and mRECIST in the assessment of therapeutic response, volumetric analysis is an efficient method for measuring HCC lesions and evaluating their response to locoregional treatment.
 

DOI

10.21608/scumj.2024.345576

Keywords

Barcelona Clinic Liver Cancer, Solid Tumors

Authors

First Name

Gehad NH.

Last Name

Mousa

MiddleName

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Affiliation

Department of Diagnostic Radiology, Ismailia Oncology Teaching Hospital. Egypt.

Email

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City

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Orcid

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First Name

Tarek H.

Last Name

Khalil

MiddleName

-

Affiliation

Department of Diagnostic Radiology, Faculty of Medicine, Suez Canal University, Egypt.

Email

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City

-

Orcid

-

First Name

Marwa A.

Last Name

Suliman

MiddleName

-

Affiliation

Department of Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

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City

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Orcid

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First Name

Ahmed T.

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Diagnostic Radiology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

2

Related Issue

46317

Issue Date

2024-02-01

Receive Date

2024-03-13

Publish Date

2024-02-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_345576.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=345576

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Role of Multi-Detector Computed Tomography in Tumor Response Evaluation of Conventional Trans-Arterial Chemoembolization in Hepatocellular Carcinoma

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Type

Article

Created At

24 Dec 2024