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321285

Short-Term Impact of Hyperuricemia in Acute Coronary Syndrome among Coronary Care Unit Patients in Suez Canal Authority Hospital and Ismailia Medical Complex

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Uric acid is an independent risk factor for cardiovascular disease. Although studies were conducted abroad regarding the association of serum uric acid with in-hospital outcomes in patients with acute coronary syndrome (ACS), scarce data is yet available to show the association in our country. Aim: To determine the level of uric acid level in acute coronary syndrome patients, to assess the relation between hyperuricemia and its impact on the severity of acute coronary syndrome patients, and to assess the correlation between hyperuricemia and age in patients with ACS. Subjects and Methods: A cross-sectional comparative study was done in the Department of Cardiology, Suez Canal Authority, and Ismailia Medical Complex Hospitals. After proper ethical consideration, a total of 200 ACS patients were enrolled in the study by nonrandom sampling. Serum uric acid of all subjects was measured within 24 hours of admission, 3, 5, and 7 days after admission. Then in-hospital outcomes were observed in all subjects. Results: Died patients had a statistically significantly higher median of uric acid at admission, 3 days, 5 days, and 7 days after that survived patients. Age, DM, HTN, and death had significant direct correlations with serial uric acid measurements. Also, Killip class and CK-MB had significant direct correlations with serial uric acid measurements at admission and after 3 days of admission. Age, DM, HTN, Killip class, and hyperuricemia were significant predictors of death. Conclusion: ACS patients with hyperuricemia had a higher risk of death, even after adjustment for conventional risk factors. Measurement of uric acid levels has the potential to improve risk classification in ACS patients.
 

DOI

10.21608/scumj.2023.321285

Keywords

myocardial infarction, Uric acid

Authors

First Name

Mohamed A.

Last Name

Khalil

MiddleName

-

Affiliation

Department of Cardiology, Suez Canal Authority Hospital, Ismailia, Egypt

Email

kholio2008@yahoo.com

City

Ismailia

Orcid

0000-0001-6395-4598

First Name

Ahmed A.

Last Name

El-Hawary

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Gamela M.

Last Name

Nasr

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed Y.

Last Name

Saber

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

7

Related Issue

42539

Issue Date

2023-07-01

Receive Date

2023-10-14

Publish Date

2023-07-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_321285.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=321285

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Short-Term Impact of Hyperuricemia in Acute Coronary Syndrome among Coronary Care Unit Patients in Suez Canal Authority Hospital and Ismailia Medical Complex

Details

Type

Article

Created At

24 Dec 2024