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Serum Chemerin Levels Relation with Waist Circumference, Impaired Fasting Blood Sugar, and Dyslipidemia in Obese Children and Adolescents

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background:Obesity is known to be linked to adipokine dysregulation. Recent studies have discovered that the new adipokine chemerin is thought to be a modulator of obesity-related adipose tissue inflammation. Objectives: To compare Chemerin levels in matched obese and non-obese children and adolescents and to investigate the correlation between serum chemerin levels correlated with waist circumference, insulin resistance, and dyslipidemia. Methods: 42 obese children and adolescents, as well as 42 healthy volunteers, ranging in age from 5 to 17, took part in the study. The subjects' anthropometric and blood pressure measures were obtained. Fasting blood glucose, serum triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) were all examined by the researchers (LDL-c). The quantity of circulating chemerin was measured using an ELISA kit. Results: Compared to the control group, more than half (54.8%) of obese group patients have waist circumferences in the 90th percentile for age and gender, which is statistically significant. The obese group had a greater mean chemerin level than the control group, but the difference was not statistically significant. By using correlation and multiple linear regression analysis, serum chemerin levels were found to be significantly correlated to impaired fasting blood sugar (r= 0.398, p = 0.009) and HDL (r= -0.386, p = 0.012). Conclusions: Obese children and adolescents had higher serum chemerin levels than healthy control participants, which is linked to obesity and insulin resistance.
 

DOI

10.21608/scumj.2023.305005

Keywords

Chemerin, Obesity, body composition

Authors

First Name

Ahmed

Last Name

Ali

MiddleName

A.

Affiliation

Department of Pediatrics, El Ibrahimiya Central Hospital, Sharqia, Egypt

Email

drahmadlatif@hotmail.com

City

-

Orcid

-

First Name

Amina

Last Name

Abdel Wahab

MiddleName

M.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Suzan

Last Name

Gad

MiddleName

S.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Sanaa

Last Name

Nasar

MiddleName

S.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

3

Related Issue

41996

Issue Date

2023-03-01

Receive Date

2023-06-24

Publish Date

2023-03-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_305005.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=305005

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Serum Chemerin Levels Relation with Waist Circumference, Impaired Fasting Blood Sugar, and Dyslipidemia in Obese Children and Adolescents

Details

Type

Article

Created At

24 Dec 2024