This study examined the effects of varying levels of nano lithovit 0, 0.25, 0.50, 1.00, 1.50, and 2.00 grams per liter on the growth, production, and companionship of potato cv. Hermes during two experimental successive seasons. The study was conducted in an open field with potato crops. The registered data demonstrated that 15 cm produced greater numbers in all analyzed growth, yield, and chemical parameters, however 25 cm produced better values for tuber cracks and plant diameter throughout the course of two growing seasons. Conversely, for control and nano lithovit levels (except for 1.5), the maximum vegetative growth, yield, and chemical properties were observed at 2.00 grams per liter for nano material only in the second season did the comparison at control and nano lithovit levels apart from 1.5 gram per liter produce the maximum plant diameter. With the exception of 1.5 grams per liter of nano lithovit with a deep 25 cm, which only produced the largest plant diameter during the second season, the application of nano lithovit at a depth of 15 cm yielded the best interaction during all potato characteristics. Throughout the two testing seasons, the control group without any lithovit had the lowest levels for every attribute. Therefore, it is advised that tubers be grown under 15 cm and that foliar application of 2 grams of nano lithovit per liter result in higher potato growth, yield, and quality along with a decrease in physiological defects of tuber production.