The shortage of food and medicines in developing countries, in addition to their high cost, is considered one of the challenges in these countries. Traditional medicine, which relies mainly on medicinal plants, could be one of the solutions to overcome these challenges, so we should preserve these plants and their genetic origin. Egypt is one of the countries that contains many medically important plants. A total of 72 taxa were recorded for medicinal and economic purposes in Belbei's Centre, Al-Sharkia Governorate, Egypt. Poaceae and Asteraceae, were the most common families represented in this Governorate. The most commonly used plant parts are the whole plant, and flowering branches, followed by the seeds, fruits, and rhizomes. The most medicinal and economical uses of the recorded species include grazing, antimicrobial activity, diuretic, and antioxidant retreatments. Many of these species in the study area have multiple medicinal and economic benefits, while few of them have limited benefits.