Background: Proper Nursing documentation covers all aspects of health care. Electronic medical records systems were needed to transform the health care system from a traditional paper-based mechanism to automated online systems. Aim of the study:  Assess' nurse knowledge regarding electronic medical records. Design: An exploratory descriptive design was used to conduct this study. Setting: The study was conducted in Intensive Care Units (ICU) at National Cancer Institute (NCI), and all nurses in intensive care units were included in the study. Tools: data were collected using nurse's knowledge questionnaire sheet. Results: 44% of nurses knew the important, function and the effect of electronic medical records, 36% of nurses knew uses of electronic medicals records and 4% of nurses considered electronic medical records a personal document. Conclusion: More than two thirds of the studied sample had unsatisfactory knowledge regarding electronic medical records. Recommendations: Health care professional schools and organizations should enhance educational programs for students and practitioners in the use of computers and Periodical training is crucial to acquire nurses with different modules that need to be learned such as scanning, charting data entry, electronic prescriptions, lab results and EMR dictation training.