Background: Restraint knowledge and practise by nurses are vital in providing nursing care to restrained patients and preventing problems. The evaluation of nurses' knowledge and practise in relation to the applied constraint impact on nursing care, as well as its weaknesses and strengths. Aim: The aim of this study is to assess nurses' knowledge and practice regarding restraints at intensive care units in Egypt Health Care Authority hospitals. Subjects and Methods: Design: Descriptive correlational study design was applied. Setting: This study was performed at ICU in the Egypt Health Care Authority Hospitals in Port Said Governorate. Sample:Convenience sample of nurses, with total number of 129 working at ICU in the time of data gathering. Tools of Data Collection: Two tools were employed for getting data: Tool I: A self-administered Nurses' Knowledge Questionnaire, Tool II: Nurses' Practice Observational Checklist. Results: The study findings showed that 68.5% of the surveyed nurses had satisfactory knowledge, highes percentage of them (93.8% ) had satisfactory practice concerning restraints; and there was a statistically significant relation among satisfactory level of nurses' knowledge and satisfactory level of nurses' practice regarding restraint for patients in ICU. Conclusion: This study finding  included that satisfactory level of knowledge and practice among nurses regarding  restraints at ICU. Recommendations:  Continues orientation an regular in serves restraining  programs for nurses in ICU regarding restraint for continues updating their knowledge.