Background: Background: Within a few weeks of application, the chemical carcinogen 7,12 dimethyl benzaanthracene ( DMBA ) causes the development of carcinomas. For pharmaceutical purposes, natural medicines (Cannabinoid), (CBD) made from plant extracts have continued to be produced. Production of all-natural, less dangerous anticarcinogenic compounds that have the potential to lessen the challenges given by neoplastic diseases like leukemic cancer. Aim of the study:- Examination of the antioxidant activity of CBD in male albino rats that were injected with DMBA. Method:- This experiment was conducted on 30 male rats sectioned into 6 groups with 5 each, Group1 (control), Group2 ( olive oil), Group3 ( cannabinoid), Group 4 ( leukemic), Group5 (prophylactic), Group 6 (Treated). Result Compared to the leukemic rat group, both the prophylactic and the CBD-treated groups. CBD was successful in returning normal levels of total white blood cells (WBC), lymphocytes, red blood cells (RBCs), haemoglobin (Hb), platelets, granulocytes, and spleen tissue. Conclusion:- Our results elucidate the ability of CBD to heal the damage caused by the toxicity effect of DMBA in the blood.