Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), was declared as a pandemic by the World Health Organization (WHO) on 11 March 2020 due to its alarming level of spread and severity the emergence and spread of COVID-19 has caused confusion, anxiety and fear. Aim of the study was to investigate relationship among COVID-19-social stigma and nurse's role efficacy. Subject and method: Research design: A descriptive correlational study design was used to conduct this study. Setting: This study was conducted at Al-Ahrar Zagazig Teaching Hospital in Zagazig, Al-sharqia, Egypt. Subjects Simple random sample was selected from nurses (n= 230). Tool of data collection: Two tools were used for collecting data:  COVID-19 social stigma scale and Nurse's role efficacy Scale (RES). Results: Studied nurses had a high level of COVID-19 social stigma and had a moderate level of nurse's role efficacy.  Conclusion: There was statistically significant negative association between COVID-19 social stigma and nurse's role efficacy. Recommendations: Strategies and measures should be taken, to reduce COVID-19social stigma , promote nurses' role efficacy by; enforcing positive public attitudes toward nurses; continuing education and training sessions; and support Health care workers in healthcare facilities should provide with occupational safety standards, equipment, consumables, training .