Background: Obstetric fistula must be eliminated to establish sustainable development by 2030 as it often results in horrific or challenge situations that frequently affect the women. Aim of the current research was to evaluate the effect of education program on maternity nurses' performance regarding obstetric fistula. Subjects and Methods: Research design:  The research methodology was a quasi-experimental one. Setting: The study was done at the labor unit of the maternity hospital at Zagazig University Hospitals in Egypt's Sharkia Governorate. Subjects: A convenience sample of 50 nurses gave women in labor direct nursing care. Tools of data collection: A self-administered questionnaire, Knowledge Assessment Sheet for Maternity Nurses, Observational Skills Checklist and Likert Scale for Maternity Nurses' Attitude.  Results: There was significant improvement in nurses' knowledge, practice, and attitudes towards obstetric fistula after application of education program compared to preprogram (р-value < 0.05). Likewise there was a positive correlation (p-value 0.05) between the nurses' knowledge assessments and their performance, attitude, and age scores. A favorable correlation between practice scores of nurses and their age and experience years was also found with statistically significant difference. Conclusion: The research hypothesis was supported and compared to before the educational intervention program was implemented, during the stages of labor, it was a very significant statistically improvement in the nurses' knowledge, practice and attitudes regarding obstetric fistula. Recommendations: Offer training courses or seminars on preventing obstetric fistulas to help nurses improve their best practices.