Abstract Background: Cervical cancer a significant health issue worldwide. Improving women hope level has a pivotal role in reducing fatigue and improve quality of life Aim: This research aimed to evaluate effect of nursing model based on Snyder's hope theory on fatigue and quality of life among women with cervical cancer Design: A quasi-experimental research (two groups pre/posttest design). Sample: 54 women diagnosed with cervical cancer. Setting: The present research conducted at obstetric & gynecological department at Helwan General Hospital, Egypt. Tools: Four tools were used for data collection: A structured interviewing questionnaire, Herth hope index, Cancer-related fatigue scale and Functional Assessment of Cancer Therapy- General. Results: There was no a statistical significant difference in the mean scores of the Herth Hope Index, Cancer-related fatigue and  Quality of life between the study and control groups at pre intervention phase (p ˃ 0.05). However, after three and six months of intervention, the mean score of the Herth Hope Index, Cancer-related fatigue and Quality of life were higher among study group than the control group with highly statistical significant difference (p ≤ 0.001).  Conclusion: Application of nursing model based on Snyder's hope theory was effective in improving level of knowledge, reducing level of fatigue and improving quality of life among woman with cervical cancer. Recommendation: All women diagnosed with cervical cancer should receive printed booklets and brochures containing component of Snyder's hope theory and how to apply it. These booklets should be kept in all obstetrics and gynecological units.