Abstract: T he present study aimed to investigate the use of case-based learning for promoting pre-service EFL teachers' pedagogical content knowledge and reducing their teaching anxiety.  The study group consisted of thirty-three (n = 33) pre-service EFL teachers enrolled in the General Diploma in Education, Faculty of Graduate Studies for Education, Cairo University. The study adopted the quasi-experimental design. A proposed case-based learning program was designed to promote pre-service EFL teachers' pedagogical content knowledge and reduce their teaching anxiety. The study instruments included a pedagogical content knowledge checklist, a pedagogical content knowledge test, and a language teaching anxiety scale. The data were analyzed qualitatively and quantitatively. Despite the limitations in the design and execution of the study, the proposed case-based learning program improved pre-service teachers' pedagogical content knowledge and reduced their teaching anxiety.