Background: Job crafting is an example of constructive behavior in which workers aggregate resources to meet their needs which increases their job satisfaction and leads to decrease counterproductive work behaviors. Aim: This study aimed at assessing the relation between job crafting, staff nurses' job satisfaction and counterproductive work behaviors. Research design: A descriptive, correlational design was used. Setting: The study was conducted at Ain Shams University hospital. Subjects: 169 staff nurses were included in the study using simple random sampling technique. Tools of data collection: Data were collected by using job crafting scale, nurses' job satisfaction scale, and counterproductive work behavior questionnaire. Results: More than half 58% of studied staff nurses had low job crafting level, half (50%) of them had high job satisfaction level and half of them (50%) had high engagement in Counterproductive Work Behavior level. Conclusion: there was negative significant correlation between job crafting and counterproductive work behavior. Moreover, there is negative significant correlation between job satisfaction and counterproductive work behavior Recommendations: Take corrective disciplinary approaches, actions and strategies against counter productive work behaviors. Provide fair amount of bonuses and incentives for appreciating positive behaviors of staff nurses.