Background: - First aid intervention can lower the disability and increase the chances of survival of the injured child. Mothers as caregivers are playing a vital role in the prevention of childhood injuries. They are the primary persons who can help the children and perform first aid on them so that, they can prevent complications and sometimes prevent death. Most of these accidents are preventable through increased mothers' awareness and improvements in the home environment. Aim: To evaluate the impact of a structured educational package on new mothers' knowledge and practice regarding first aid management among their children. Research design: A Quasi-Experimental design (one group pre/post design) was utilized in the current research. Settings: This study was conducted at Pediatric Outpatient Clinics at Sohag University Hospital.  Subjects: A convenience sampling of all new mothers (200) who were present at the time of data collection from the previously selected setting within six months. Tools: (I): Personal data of the mother, (II): Mothers' knowledge about first aid management, and (III): Mothers' reported practice about first aid management. Results: The current results revealed significant differences and improvements in knowledge and practice scores about first aid management post-structured educational package implementation than pre-structured educational package implementation. There was a positive statistically significant correlation between the total knowledge score and total practice score about first aid management. There was a highly significance relation between mothers' knowledge and practices regarding first aid management and their age and education. There was a highly significant relationship between mother's practices and education. Conclusion: the study concluded that structured educational package has a positive effect on improving newly mothers' knowledge and practice regarding first aid management among their children. Recommendations: Training courses about first aid must be provided to mothers in pediatric settings. Health members should continue their teaching about first aid periodically in pediatric settings. Media such as TV should also, introduce information about common children's injuries, and first aid management.