Background: Assessing patients' requirements and providing comprehensive nursing care are crucial aspects of the role nurses play in providing end-of-life nursing care to patients who have life-threatening illnesses and have not responded well to medical therapy. Aim: This study aimed to determine the effect of social-platform nursing education on nurses' knowledge and practices regarding end-of-life care. Subjects and method: Design: A quasi-experimental research design was utilized to achieve the aim of the current study. Setting: The study was applied in the medical and general intensive care units at Sohag University Hospital. Subjects: A purposive sample included 100 nurses who work in the previously listed setting were included in the study. Tools for data collection: Tool one: structured Interview questionnaire and developed after reviewing related literature and consisted of two parts. Part one: Nurses' personal data as nurses; Part two: Nurses' knowledge questionnaire and Tool two: Performance checklist used to assess nurses' level of practice regarding end-of-life care. Results: The study result portrayed that knowledge and practice pre and post-two months of social-platform nursing education; there was a statistically significant difference. Conclusion: Social-platform nursing education was effective and significantly improved nurses' knowledge and practice. Recommendations: We recommend social-platform nursing education to improve nurses' knowledge and practices regarding end-of-life care should be encouraged.