Background: Nursing students are more susceptible to perceived adversity and stress than other healthcare majors. Otherwise, in nursing training, students are confronted with real patient/clinic scenarios and numerous innovations, including death and dying, various lifestyles, and infectious diseases, are presented to nursing students during their training. Fostering resilience in students can aid in their academic completion and practice readiness. Aim: This study aimed to examine the attributes of resilient university students across mindfulness, psychological distress, and sleep disturbances. Design: This study used a cross-sectional descriptive correlational design Subjects: involved a convenient sample of 195 nursing students. Setting: It was conducted at the faculties of nursing at Cairo University and Fayoum University.  Tools of Data Collection: Five tools for data collection were used: A demographic data sheet, Resilience Scale, General Health Questionnaire composed of 30 items, Sleep disturbance scale & Freiburg Mindfulness Inventory. Results: The study showed that there was a highly significant difference between the mean of total scores of the “Resilience Scale", “General Health Questionnaire", and “Sleep Disturbance Scale" results for the study group between Cairo University and Fayoum University nursing students. Conclusion: The study concluded that resilience and mindfulness are effective care methods for reducing psychological distress. Recommendation: Nursing students require a training program that emphasizes mindfulness and resilience. Therefore, requiring resilience encourages positive reductions in psychological distress among college students. This has significant ramifications for current and upcoming studies on the population of university students' resilience and mental health.