Background: Percutaneous nephrostomy tube (PCN) is a widely utilized interventional procedure for upper urinary diversion and decompression of the renal collecting system. Caring for patients with a percutaneous nephrostomy is a critical component of nursing management to minimize complications and improve the health status of those patients. However, there is inadequate information for nurses and a lack of evidence and guidance. One of the most effective ways to support nurses' personal and professional development is coaching. Aim: To evaluate the impact of coaching intervention program on nurses' performance regarding caring for patients undergoing percutaneous nephrostomy tube. Method: A quasi-experimental design was used to conduct this study (pre/post-test) to achieve the aim of the study. Setting: The research was carried out in the urology department at Sohag University Hospital. Sample: A convenient sample of all available nurses (50) worked at the previously mentioned setting. Tools of data collection: Three tools were used; Tool (I): Structured interviewing questionnaire consisted of two parts: Part (1): Personal data of the nurses. Part (2): Nurses' knowledge questionnaire, Tool (II): Nurses' observational checklist and Tool (III): Coaching Practice Rating Scale, used by the nurses as a self-evaluation instrument to reveal the degree to which their coaching practices. Results: The majority of the nurses in the study had higher levels of practice and knowledge after the coaching intervention program than they did before, according to the study's findings. Furthermore, a statistically significant correlation was seen between the total ratings for the knowledge and practice of nurses. Conclusion: The coaching intervention program enhanced the coaching abilities and performance of nurses in the area of patient care for those undergoing percutaneous nephrostomy tubes. Recommendations: To improve their abilities as coaches and caregivers of patients having percutaneous nephrostomy tube placement, nurses should consistently implement the coaching intervention program.