Background Pemphigus Vulgaris is a skin disease recognized for its characteristic autoantibody production, which assail skin proteins, leading to the formation of blisters and erosions that require special nursing care to maximize patients' health outcomes. This study aimed to conclude the effect of imposing a protocol of nursing care on pemphigus vulgaris patients' clinical health outcomes. Methods: The study encompassed a convenience sample of 50 subjects and conducted a quasi-experimental research design. Tool 1: Bio-sociodemographic-constructed Interview:  the tool's primary use is to identify patients' socio demographic and clinical data Tool 2: severity of pemphigus vulgaris assessment sheet this tool was used to evaluate the severity of the illness Tool 3: the Dermatological Quality of Life index (DQOLI): used to assess the influence of the illness on the patient's life-quality during the last week. Results: there were statistically significant difference in all items of dermatology quality of life index pre and post nursing's care protocol application and in Kumar's oral and skin scoring preceding and subsequent to enforcing the nursing's care. Conclusions. Nursing's care protocol was effective in improving patients' clinical health outcomes Recommendations: Creation of an educational unit for Nursing Care on Pemphigus of Vulgaris Patients in the dermatology hospital departments. Conducting similar studies on a larger probability sample is recommended to achieve generalization of the findings.