Background: Pressure injuries are a common and frustrating problem affecting the elderly in geriatric care home settings. Lack of caregiver knowledge and practices about pressure injury prevention contributes significantly to the occurrence or worsening of pressure injuries. Aim: This study aims to evaluate the effect of the pressure injury prevention training program on caregivers's knowledge, attitude, and practices in selected geriatric care homes. Methods: A quasi-experimental design was applied to 50 caregivers providing care in three private geriatric home care in El Sheikh Zayed City, (Malak El-Kheer, Malak EL-Rahma, and El-Jasmine). Tools: Two tools were used: (I) An interviewing questionnaire for the caregiver's demographic characteristics, caregiver's knowledge, and attitude towards pressure injury prevention. (II) Observation checklist for therapeutic repositioning among immobilized elderly.  Results: The present study revealed that: the mean caregivers' s ages were 33.26 ± 4.20, and (70%) of them were females, additionally, the total percentage score levels of satisfactory knowledge and positive attitude were (54%) and (47%) pre-program, respectively, compared to (86%) and (95%) post-program with a statistically significant difference, as (X² =10.33, and X² =11.005, p= 0.000), also, there is an improvement in the total percentage score levels of satisfactory observed practice of therapeutic repositioning of immobilized elderly among studied caregiver's pre-program was (34%) compared to post-program (92%) with a statistically significant difference, as (X² =11.75, p= 0.016). Conclusion: Applying a pressure injury prevention training program for elderly caregivers significantly improved the knowledge, attitude, and practices of the studied caregivers in the geriatric care homes. Recommendations: The necessity for constant training programs for elderly caregivers in elderly home care settings regarding pressure injury prevention knowledge, attitude, and practices for achieving competence in caring for elderly residents.