Aim: The study aims to assess nurses' knowledge and practice regarding care of children undergoing liver surgeries. Research design: A descriptive study design was used. Setting: The study was conducted at Pediatric Surgery Unit in the Children's Hospital that affiliated to Ain shams university hospitals and Liver Surgeries Unit that affiliated to Air Force Specialized Hospital / Cairo/ Egypt. Sample: A purposive sample of 50 nurses, from the previously mentioned setting during the period of six months. Tools: two tools were used to collect data namely: A structured interviewing questionnaire and standardized observational checklists adopted from (Perry et al., 2018) to assess nurses' knowledge and practice regarding care of children undergoing liver surgeries. Results: showed that near quarter of the studied nurses had satisfactory total knowledge levels regarding care of children undergoing liver surgeries, and only 28% of them had competent total practice regarding care of children undergoing liver surgeries. There were statistically significant differences between nurses' knowledge and practices regarding care of children undergoing liver diseases and surgeries and their socio-demographic characteristics. Conclusion: Nurses' knowledge and practice regarding care of children undergoing liver surgeries were unsatisfactory by majority of the studied sample. Recommendation: Adopt nursing intervention based on actual need assessment of nursing regarding care of children undergoing liver surgeries.