Background: Delirium is a common, potentially fatal, and avoidable cause of morbidity and death in patients in the intensive care unit. Delirium that is left untreated raises the risk of death, morbidity, and functional decline. This results in a greater need for nursing care, higher medical expenses, and longer hospital admissions. Numerous studies show that nurses' approaches and expertise regarding delirium are inadequate. So, the study aimed to evaluate the Impact of psycho-educational programs on nurses' performance regarding the care of patients with delirium in the intensive care unit. Design: A quasi-experimental research design was used to achieve the aim of this study. Setting: This study was conducted in the intensive care unit at Sohag University Hospital. Sample: - A convenient sample of 50 nurses working in the previously selected setting. Tools: Three tools were used: Tool I: Nurse's knowledge assessment sheet regarding delirium, Tool II: Nurse's reported practice caring for patients with delirium, and Tool III: Nurse's satisfaction with the psycho-educational program. Results: The mean scores of intensive care unit nurses about their knowledge and practices regarding the care of patients with delirium have significantly improved since the implementation of the psycho-educational program. When compared to pre-psycho-educational programs, the study's results showed that most of the nurses under investigation had satisfactory knowledge and competent practices. The total knowledge and practices of nurses before and after the psycho-educational program showed a good association. Conclusion: The study found that a psycho-educational program on delirium improved nurses' performance in providing delirium patients with care in an intensive care unit. Recommendations: Nurses should be offered a carefully thought-out psycho-educational program to enhance their delirium performance.