Background: Parkinson's disease (PD) is a prevalent degenerative neurological condition that lowers quality of life and results in loss of independence. Studies directly comparing the clinical efficacy of different Tai Chi exercises in treating anxiety and stress symptoms in older adults are still rare, despite the growing body of evidence supporting the beneficial effects of Tai Chi in reducing these symptoms. Therefore, the current study aimed toevaluate the effectiveness of Tai Chi exercise application on stress and anxiety among patients with Parkinson's disease. Study design: A quasi-experimental research design was usedto fulfill this study using a pre-test and post-test one-group design. Setting: The study was conducted in the neurologyoutpatient setting at SohagUniversity Hospital. Subjects: the study included a convenient sampling technique of 100 patients with Parkinson's disease. Tools of data collection:Three toolswere usedfor data collection;Tool I:Personalassessment datasheet, Tool II: Perceived Stress Scale-10 (PSS-10), and Tool III:The State-Trait Anxiety Inventory. Results:Astatisticallysignificant difference was found between stress mean scores and anxiety at (P=0.001) pre and post-Tai Chi exercise application. Also, a substantial reduction in pre- and post-Tai Chi exercise application between the groups was reported regardingstress and anxiety levels. Conclusion: TheTai Chi exercise application has a significant decrease in mean post-test stress and anxiety among patients with Parkinson's disease.  Recommendations: It is stronglyadvised to apply a training program for patients with Parkinson's diseaseabout the importance of the Tai Chi exercise application to be able to use them as a part of routine care.