Background: Staff nurses face various stressful situations may affect their mental health and ability to provide care, so resilience and moral intelligence, are of great importance to improve nurses' problem-solving abilities, coping strategies and avoid extreme emotional responses and professional compatibility to achieve effective organizational outcomes. Aim: Assess staff nurses' resilience and its relation to moral intelligence and professional compatibility. Design: A descriptive correlation research design. Setting: At critical care units and departments in Shebin El Kom Teaching Hospitals and outpatient clinics departments. Study subjects: A convenient sampling technique include (226) staff nurses were participated in the study. Tools: Three tools were used named Connor–Davidson Resilience Scale, Moral Intelligence Questionnaire and Professional Compatibility Scale. Results: The study findings indicated that there were a high percentage of participant staff nurses at high level of resilience (69 %), moral intelligence (63.50%) and professional compatibility (61.50%). Conclusion: the study concluded that, there was a high positive statistical significance correlation between participant staff nurses' resilience, moral intelligence, and professional compatibility. Recommendations: Nursing educational institutions ought to equip graduates with rational thinking, perception of personal competence and acceptance of change to im