Background: One of the most critical surgeries performed on the human body is brain surgery. Its concern potentially results in death or neurological impairment of cognitive, psychological, emotional, and behavioral skills from the brain. Also, mental health issues occur because of some dysfunction of the brain. Aim: This study aimed to evaluate the effect of implementing a designed rehabilitation nursing intervention for brain surgery's patients on their physical and psychological status. Design: A quasi-experimental research design was utilized to achieve the aim of this study. Setting: This study was conducted in Neurosurgery inpatient and outpatient clinics also, oncology clinics at Beni-Suef University Hospital, Egypt.  Sample: A purposive sample of consisted of fifty adult patients undergoing brain surgery was collected within six months. Tools of data collection: Tool I: Brain Surgery Patients' Knowledge Assessment Sheet, Tool II: Brain Surgery Patients' Practices Assessment Questionnaire, Tool III: The short Form 12 (SF-12), Tool IV: The Hospital Anxiety and Depression Scale (HADS), and Tool V: The Impact of Event Scale (IES). Results: Regarding patients' knowledge, anxiety depression, and stress there a highly statistically significant differences and improvements was found between the designed rehabilitation nursing intervention and the pre-intervention among the studied patients. Conclusion: The results concluded that implementing a designed rehabilitation nursing intervention has a positive effect on improving physical and psychological status among brain surgery patients. Recommendation: It is recommended that every patient having brain surgery should get a rehabilitation program. All patients having brain surgery should have access to the prepared booklet brain surgery. Emotional support should be provided to patients undergoing brain surgery. Further research on a larger sample is recommended to achieve generalization. Further study is recommended to evaluate physical and psychological assessment before and after the surgery.