Background: Systems thinking (ST) is a crucial component of nursing education and practice. It helps nursing students understand the nature of the situations. they face in clinical areas, view topics from a broad perspective, and make the right decision in complicated situations. Furthermore, it is an intrinsically motivating factor that encourages nursing students to have favorable attitudes towards their clinical practice. Aim: To determine the relationship between systems thinking and attitudes towards clinical practice as perceived by nursing students. Design: A descriptive correlational research design was utilized to conduct this study. Setting: This study was conducted at all scientific departments at Faculty of Nursing, Damanhour University. Subjects: Probability simple random sample from students (n=365) enrolled in the second, third, and fourth academic year in the Faculty of Nursing, Damanhour University 2022-2023, who were available during the time of data collection. Tools: two tools were used. Tool one: “Systems thinking pattern survey". Tool two: “Attitudes towards clinical practice questionnaire". Results: The results of this study revealed that there were statistical significant differences between faculty of nursing students in the three academic years regarding their levels of ST pattern (p=0.041). Also, more than two-thirds of the faculty of nursing students (69%) perceived moderate level of systems thinking pattern. Concerning levels of attitudes towards clinical practice and its dimensions, namely enthusiastic attitude and querulous attitude there were no statistical significant differences among faculty of nursing students in the three academic years (p=0.074, p=0.456, p=0.111), respectively. Also, the majority of the faculty nursing students (85%) perceived fair overall attitudes towards clinical practice mainly in the 3^rd and 4^th academic years (84.7%, 89.6%), respectively. Conclusion: The finding of this study concluded that, there was a high statistical significant correlation between the overall systems thinking pattern and the overall attitudes towards clinical practice as perceived by faculty nursing students in the three academic years (r=0.210, p<0.001). Recommendations: Conduct frequent training programs and a series of workshops on systems thinking for academic professors, clinical instructors, and faculty of nursing students to increase their systems thinking knowledge and skills.