Background: Mothers of children with Burkitt lymphoma play a crucial role in the process of children's management and full fling the children's needs during the treatment period. Aim: This study aimed to assess the Mothers' Role towards Management of Their Children with Burkitt's Lymphoma. Research Design: A descriptive design was used to achieve the aim of this study. Subjects: A purposive sample consisted of 60 mothers with their children with Burkitt's lymphoma. Tools of data collection: Two tools were included: Tool I: A interviewing structure questionnaire and Tool II: Medical records. Results: 63.3% of children did not achieve their health needs, 97.7% of children did not have health problems, also, 91.7% of the mothers had an unsatisfactory level of knowledge, while 81.7% of mothers had total satisfactory practice, and 91.7% of the mothers had a negative attitude. Conclusion: Based on the present study findings it can be concluded that all the children achieved physical needs, and nearly most of them had health problems. Moreover, there was a positive correlation between mothers' practice and mothers' knowledge regarding the management of their children with Burkitt's lymphoma. Recommendation: Increase awareness of the mother's knowledge about Burkitt lymphoma in diagnosis and treatment. Also, increase the nursing instructions for mothers of children with Burkitt lymphoma on the health needs and problems of their children with Burkitt lymphoma.