Background: Corona virus was spread almost all over the world and was seen in thousands of people and caused thousands of people to die. Isolation precautions are intended to prevent transmission of infectious agents, yet health care provider (HCP) adherence remains suboptimal. This study aimed to assess nurses' performance about isolation precautions regarding Covid-19 patients in intensive care units. Design: A descriptive exploratory research. Subjects: A purposive subjects composed of (60) nurses who work in covid-19 Intensive Care Unit. Tools: 1) Nurses' knowledge questionnaire about Isolation Precautions, 2) Observation checklists and 3) Nurses' attitude questionnaire regarding Isolation Precautions. Results: less than three fifths of the studied nurses had a satisfactory level of knowledge. Moreover, vast majority of the studied nurses had unsatisfactory practices. Additionally, more than half of the studied nurses had a positive attitude regarding corona virus and isolation precautions. Conclusion: there was a positive correlation between nurses' knowledge and nurses' practice. The study Recommendations: Continuous nursing education and in- service training programs of nurses should be organized to upgrade the knowledge, practice and attitude of nurses.