Background: The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 syndrome is one of those challenges, having become increasingly common as the pandemic evolves. Post-COVID Conditions are a wide range of new, returning, or ongoing health problems that people experience after being infected with the virus that causes COVID-19.the WHO is a set of ‘signs and symptoms that emerge during or after an infection consistent with COVID-19, persist for more than 12 weeks, and are not explained by an alternative diagnosis' Aim: The aim of the present study was to assess women's knowledge, practice, attitude related to post covid-19 syndrome. Design: A descriptive analytical study design was utilized. Setting: The study was conducted at two health unit (Ebheet Elhagr and Sennors medical units) at Fayoum governorate. Sample: A purposive sample of (230) women according certain criteria; who aged 20-50 years and contracted covid-19.Tools of data collection: three tools was used for data collection. An Interviewing questionnaire to assess knowledge, reported practice of women regarding Post covid-19 syndrome and attitude Likert scale to assess attitude of women regarding Post covid-19 syndrome. Results: The study revealed that the 80% had unsatisfactory level of knowledge about Post covid-19 syndrome, about 90.4% had satisfactory practice towards Post covid-19 syndrome, 43.5% of the study group had a positive attitude towards Post covid-19 syndrome, 56.5% had negative attitude. Conclusion. There were a statistical significant difference between women's education, occupation, family income and total women's knowledge. And women with satisfactory knowledge show a satisfactory level of practice while there was no significant association between attitude and knowledge level and there was no significant association between attitude and reported practice level. Recommendation: health educational program for women's to enhance knowledge, practices and attitude regarding to COVID syndrome through design health educational program, brochure and booklets.