Background: Advanced health program on patients' outcomes after endoscopic treatment of bleeding peptic ulcers is considered as a strategy for promoting patients' outcomes at home and in the community. Aim: The study aimed to evaluate the effect of advanced health program on patients' outcomes after endoscopic treatment of bleeding peptic ulcers through the following: 1) Assess needs of patients after endoscopic treatment of bleeding peptic ulcers.2) Develop and apply the advanced health program on patient after endoscopic treatment of bleeding peptic ulcers based on patients identified needs.3) Evaluate the effect of advanced health program on patients' outcomes after endoscopic treatment of bleeding peptic ulcers. Study design: a quasi-experimental design was utilized to conduct this study. Setting: The study was conducted in the endoscopic unit at El Demerdash surgical hospital and outpatient clinics at Ain Shams University hospital, Cairo governorate, Egypt. Subject: A purposive sample of 134 patients was recruited in this study based on power analysis. Data collection tools: 1) Patients' Interviewing questionnaire. 2) Patient's health outcomes assessment tool. 3) Modified Fatigue Impact Scale (MFIS). Results: the present study revealed that, mean age of the patients under study was 52.63±7.6 and 56% of them were males, there was a highly statistically significant difference of patients' total satisfactory level of knowledge about bleeding peptic ulcer during the three phases of the study (pre, post ad follow up).And there were a highly statistically significant difference of patients' total nutritional practices related to bleeding peptic ulcer during the three phases of the study. Also that there were a highly statistically significant difference of patients' total physical status related to bleeding peptic ulcer during the three phases of the study. And there was a statistically significant relation between patients' physical status and their level of education and living condition immediately post and one month after implementing advanced health program Conclusion: Application of advanced health program has positive effect on improving outcomes of patients after endoscopic treatment of bleeding peptic ulcers. Recommendations Counseling interventions should be added to the routine nursing care delivered to those patients in all treatment clinics and should be updated periodically to enhance their knowledge and improve their physical and psychological wellbeing.