Background: One of the most frequent types of fractures is proximal humeral fracture. Persons with shoulder injuries have a gradual and continuous recovery from their injury and also, many people have persistent disabilities that interfere with their daily routines. So, the aim of the present study was to explore the efficacy of a therapeutic exercise program on patients' pain and shoulder mobility following proximal humeral fracture surgery. Research design: To accomplish the goal of this study, a quasi-experimental research design was employed. Setting: The study was conducted in the orthopedic unit at Menoufia University Hospital. Sample: Within six months after surgery for proximal humeral fractures, a convenient sample of fifty patients was included in the current study. Tools for data collection: (I): Structured interview questionnaire, II: Numerical Rating Pain Scale, and Tool III: Shoulder function index. Results: There was a statistically significant difference improvement in the total mean score of the pain and shoulder mobility post therapeutic exercise program application among patients post-humeral fracture surgery. Conclusion: Therapeutic exercise program application has a significant effect on reducing pain and improves shoulder mobility among patients following proximal humeral fracture surgery. Recommendations: It is advised that patients undergoing proximal humeral fracture surgery get a therapeutic exercise program as a crucial component of their nursing education.