Background: Pediatric tracheostomies are associated with risks and it is increasingly being used to treat upper-airway congestion in kids with complicated and long-term illnesses.. Aim: to evaluate the effectiveness of TRACHE care bundle implementation on the Pediatric Nurses' performance and improving pediatric tracheostomy management safety. Method: The design used was quasi-experimental. Sample: A convenience sample of all available bedside/ working nurses and children undergoing tracheal intubation at Neonatal and Pediatric Intensive Care Units at Aswan university  hospital. Data collection utilized three tools: A structured interview questionnaire encompassing biosocial data for nurses and children, nurses' knowledge, an observation checklist to assess nurse practices regarding TRACHE care bundle guideline, and an assessment of checklist observation related pediatric tracheostomy management safety . Results:  According to this study, the majority of nurses had inadequate tracheostomy care knowledge and practice before program implementation (80.4% and 64.3%, respectively), and these levels sharply dropped right after the program (37.5% and 32.1%, respectively). Conclusion: there was significant improvement in nurse's knowledge and practices regarding tracheostomy care post the program implementation which supported the study hypothesis. Recommendation: educational training program should be applied to a broader sample of nurses drawn from different regions of Egypt to improve the effectiveness of their tracheostomy care