Background: Nurses who view their job environments as friendly and supportive are more suitable to show favorable behaviors and excellent performance. Besides, a suitable workplace civility climate helps to inspire innovative behavior .Aim: this study aims to determine the relation of workplace civility climate and innovative work behavior from staff nurses' perspective. Design: A descriptive correlational research was used in the study. Setting: The study was conducted at critical care units and departments in Shebin El Kom Teaching Hospitals. Study subjects:    A convenient sampling technique was used in the current study n=226. Tools: two instruments were used in this study, the instrument one was workplace civility climate consisted of 22 items and instrument two innovative work behavior questionnaire consisted of 24 items. Results: the studied sample had moderate level of workplace civility climate and innovative work behaviour. Also, that there was highly positive statistical significance relation between staff nurses' total perception level regarding workplace civility climate and innovative work behavior. Conclusion: there was highly positive statistical significance between workplace civility climate and innovative work behaviour. Recommendation: The management of healthcare organizations should create a workplace civility climate to cultivate nurse's innovative work behavior.